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      • Open Access Article

        1 - High intensity interval training and Eryngium billardieri extract consumption on MMP-2 gene expression of visceral fat in rats with metabolic syndrome
        Mostafa  Haji Gholami Shahin Riyahi Malayeri Asal   ziloubaf Hedyeh Hassanpour
        Background: Metabolic syndrome includes a set of metabolic disorders that expose the patient to cardiovascular disease and diabetes. The aim of the present study was to evaluate the effect of High intensity interval training and Eryngium billardieri extract consumptio Full Text
        Background: Metabolic syndrome includes a set of metabolic disorders that expose the patient to cardiovascular disease and diabetes. The aim of the present study was to evaluate the effect of High intensity interval training and Eryngium billardieri extract consumption on the expression of visceral fat matrix metalloproteinase-2 gene and insulin resistance in rats with metabolic syndrome. Methods: In this experimental study, 32 male Sprague-Dawley rats weighing 200-250 g were randomly divided into 4 groups: 1- Healthy group 2- Metabolic syndrome 3- Metabolic syndrome + Eryngium billardieri 4- Metabolic syndrome + Eryngium billardieri + HIIT. The training protocol was performed on a rodent treadmill for 8 weeks and 5 sessions per week and 125 mg of Eryngium billardieri extract per kilogram of body weight was given by gastric gavage 5 days a week for 8 weeks. At the end of the eighth week, sample of visceral adipose tissue was taken to examine the expression of MMP-2 gene. Animal blood was collected from the heart. ANOVA were used for data analysis using SPSS 23 software at a significant level (p <0.05). Tukey significance test was used to compare significant differences. Results: Eight weeks of intense intermittent exercise with consumption of Eryngium billardieri extract caused a significant decrease in MMP-2 gene levels and glucose and insulin levels in comparison with the metabolic syndrome group (P <0.05). Conclusion: According to the results of the study, it seems that High intensity interval training with the use of Eryngium billardieri extract helps to improve insulin resistance and reduce MMP2. Manuscript Document
      • Open Access Article

        2 - Moderate aerobic exercise and probiotic intake on FOXA1 gene expression in non-alcoholic fatty liver animal model: An Experimental Study
        Shahin Riyahi Malayeri Hamzeh  MohamMadi Firooz Abad Omid   Soleimani Ghaleh Soheila   Azarkhosh
        Background: Fatty liver disease is also known as fatty liver syndrome and is also called hepatic steatosis the aim of this study was to evaluate the effect of eight weeks of aerobic exercise and probiotic intake on FOXA1 gene expression in rats with fatty liver. Metho Full Text
        Background: Fatty liver disease is also known as fatty liver syndrome and is also called hepatic steatosis the aim of this study was to evaluate the effect of eight weeks of aerobic exercise and probiotic intake on FOXA1 gene expression in rats with fatty liver. Methods: This study is an experimental laboratory study. Thirty-two male wistar rats were divided into 4 groups of 8 in the healthy, steatosis, steatosis + probiotic, steatosis + probiotic +aerobic exercise groups and tested for 8 weeks. The exercise protocol was as follows: in the first week from 10 minutes of running at a speed of 18 meters per minute to the eighth week with 60 minutes of running at a speed of 28 meters per minute. Consumption of probiotics; Relevant groups received 109 CFU / ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. RT-pcr method was used to evaluate the expression of FOXA1gene. ANOVA were used for data analysis using SPSS 23 software at a significant level (p <0.05). Results: The results showed that eight weeks of aerobic exercise with probiotic intake had a significant decrease on the expression of FOXA1 gene and LDL in rats with fatty liver (P <0.05). Conclusion: According to the results of the study, It seems that aerobic exercise with probiotics intake can improve the liver function of non-alcoholic fatty liver patients. Manuscript Document