• List of Articles


      • Open Access Article

        1 - Circulating concentrations of the BATokine 12,13-dihydroxy- 9Z-octadecenoic acid (12,13-diHOME) in different types of exercise training
        Mehdi Zargani Ehsan Arabzadeh Fariba  Aghaei Yosef   Ebrahimpour
        According to the investigation, Lipokines are a kind of bioactive compounds, derived from adipose tissue deposition, which manages multiple molecular signaling pathways. In recent years, 12,13-dihydroxy-9Z-octadecanoic acid (12,13-diHOME), an Oxylipin, has become increa Full Text
        According to the investigation, Lipokines are a kind of bioactive compounds, derived from adipose tissue deposition, which manages multiple molecular signaling pathways. In recent years, 12,13-dihydroxy-9Z-octadecanoic acid (12,13-diHOME), an Oxylipin, has become increasingly important in the scientific literature. An increase of 12,13-diHOME in circulation was associated with an improvement in metabolic health, and the action of this molecule seems to be mediated by brown adipose tissue (BAT)(1). In fact, Oxylipins are oxidized metabolites of long-chain polyunsaturated fatty acids (PUFAs). PUFAs may be received immediately from the weight loss program or from the metabolism of linoleic acid and α-linolenic acid(2). Research indicates that Oxylipins are present in every tissue, urine and blood(3). Linoleic acid may be metabolized through cytochrome P450 (CYP) in order to produce 12,13-diHOME(4). Circulating concentrations of BATokine 12,13-dihydroxy-9Z-octadecenoic (12,13-diHOME) in rodents and humans have been shown to be elevated following exposure to cold and exercise. In other words, in mice, administration of 12,13-diHOME increased fatty acid absorption by brown/beige adipocytes and skeletal muscle after a session of moderate-intensity training, and in rodents using the same training protocol. Furthermore, investigation suggests that circulating 12,13-diHOME is associated with an increase in mitochondrial respiration capacity in the skeletal muscle. This information improves the opportunity that will increase in circulating 12,13-diHOME with exercising capabilities to assist expand the respiratory capacity of a training skeletal muscle and might increase exercise potential(5,6). Manuscript Document
      • Open Access Article

        2 - Effect of resistance training and nanocurcumin supplementation on the expression of FNDC5 and PPARƔ genes in rat muscle tissue
        Amir Maleki Masoumeh Hosseini
        Background: Irisin is released from the Fndc5 protein in muscle cell through physical activity and effects on metabolism through browning of white fat. The purpose of this study was to the effect of resistance training and supplementation of nanocurcumin on the expressi Full Text
        Background: Irisin is released from the Fndc5 protein in muscle cell through physical activity and effects on metabolism through browning of white fat. The purpose of this study was to the effect of resistance training and supplementation of nanocurcumin on the expression of genes of FNDC5 and PPARɣ rat muscle tissue. Materials and Methods: In this experimental study, 32 rats were randomly divided into four groups (Control, resistance training, nanocurcumin, resistance training + nanocurcumin). The training groups program included 4 weeks, 3 days a week from climbing on a stepladder. Nanocarcmine (80 mg / kg) was given gavage in complementary groups for four weeks daily. FNDC5 and PPARƔ gene expression were measured using the RT-PCR method. Data were analyzed using one-way ANOVA with a significant level of P≤0.05. Results: The results showed that resistance training and supplementation of Nanocarcmine significantly increased the expression of the gene of FNDC5 and PPARɣ in muscle tissue of rat (P <0.05). Conclusion: It seems resistance training with nanocurcumin supplementation may stimulate secretion of FNDC5 & PPARƔ from muscle, that has a key role in the metabolism of adipose tissue and the conversion of white tissue to brown fat tissue. Manuscript Document
      • Open Access Article

        3 - Moderate aerobic exercise and probiotic intake on FOXA1 gene expression in non-alcoholic fatty liver animal model: An Experimental Study
        Shahin Riyahi Malayeri Hamzeh  MohamMadi Firooz Abad Omid   Soleimani Ghaleh Soheila   Azarkhosh
        Background: Fatty liver disease is also known as fatty liver syndrome and is also called hepatic steatosis the aim of this study was to evaluate the effect of eight weeks of aerobic exercise and probiotic intake on FOXA1 gene expression in rats with fatty liver. Metho Full Text
        Background: Fatty liver disease is also known as fatty liver syndrome and is also called hepatic steatosis the aim of this study was to evaluate the effect of eight weeks of aerobic exercise and probiotic intake on FOXA1 gene expression in rats with fatty liver. Methods: This study is an experimental laboratory study. Thirty-two male wistar rats were divided into 4 groups of 8 in the healthy, steatosis, steatosis + probiotic, steatosis + probiotic +aerobic exercise groups and tested for 8 weeks. The exercise protocol was as follows: in the first week from 10 minutes of running at a speed of 18 meters per minute to the eighth week with 60 minutes of running at a speed of 28 meters per minute. Consumption of probiotics; Relevant groups received 109 CFU / ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. RT-pcr method was used to evaluate the expression of FOXA1gene. ANOVA were used for data analysis using SPSS 23 software at a significant level (p <0.05). Results: The results showed that eight weeks of aerobic exercise with probiotic intake had a significant decrease on the expression of FOXA1 gene and LDL in rats with fatty liver (P <0.05). Conclusion: According to the results of the study, It seems that aerobic exercise with probiotics intake can improve the liver function of non-alcoholic fatty liver patients. Manuscript Document
      • Open Access Article

        4 - The effects of detraining following a regular exercise program on plasma resistin concentrations in asthmatic patients
        Daniel Tarmast
        Background: The purpose of this study was to investigate the effects of regular exercise and the following detraining on plasma resistin concentration in patients with asthma. Climate change and reduced rainfall have caused allergies and respiratory diseases to develop Full Text
        Background: The purpose of this study was to investigate the effects of regular exercise and the following detraining on plasma resistin concentration in patients with asthma. Climate change and reduced rainfall have caused allergies and respiratory diseases to develop in different people, resulting in 8.9% of adults suffering from asthma by 2025, and 400 million by 2050. Asthma prevalence or symptoms increase as a result of the secretion of some adipokines, such as the hormone resistin. Detraining results when there is insufficient training stimulus, causing the loss of training-induced adaptations. Training cessation or insufficient training can alter the detraining characteristics. Materials and Methods: In the present study, 30 available asthmatics were randomly divided into control and exercise groups. For three months, the exercise group followed a regular training regimen that included three 90-minute sessions each week. Each training session included 60 to 85% of the patients' maximum heart rate on the treadmill or pedaling on an ergometer. The control group did not do any physical exercise in addition to their normal routines throughout the same time period. Blood samples were drawn before the first session, 2 days, and 1 month after the last sessions. Results: Serum resistin levels were not affected by the three-month regular training program or one-month detraining period. They did not differ significantly in the control group either (P >0.05). Conclusion: Despite the benefits of regular exercise being beneficial for all individuals, asthma symptoms in asthmatics were relatively reduced, although these changes were not significant. Manuscript Document
      • Open Access Article

        5 - Comparison of the effect of selected Pilates exercises, Traband training and weight training on strength and flexibility in elderly women
        Seyed Kazem Mousavi Sadati Reza Behdari
        Background: Changes in the human body due to the aging process, especially the loss of strength and flexibility of the lower limbs can increase the risk of falls. The aim of this study is to compare the effect of selected Pilates, Pilates with Traband and Pilates exerci Full Text
        Background: Changes in the human body due to the aging process, especially the loss of strength and flexibility of the lower limbs can increase the risk of falls. The aim of this study is to compare the effect of selected Pilates, Pilates with Traband and Pilates exercises with both factors such as strength and flexibility of the lower extremities of non-athlete 50-60 years old. Materials and Methods: Thirty participants in this study have been randomly divided into three groups: quasi-experimental, Pilates (10), Pilates Traband (10) and Pilates (10). Before the beginning of the exercises, the strength of the lower limbs and static acceptance and the range of motion of extension and flexion of the thigh have been measured using the test of 30 sitting on a chair, static acceptance and goniometer, respectively. Moreover, all three groups as participated in a course of exercise. These exercises have performed for 8 weeks, 3 sessions per week for 1 hour and have performed after the participants. Data have been analyzed using paired t-test and ANOVA. Results: As result, all three groups show the significant progress due to exercise but there is not any significant variance between the groups, as none of the methods is not better than other training methods. Conclusion: performing Pilates exercises, Weight and Traband based on the availability of training equipment and facilities, is beneficial for the elderly, and this exercise may reduce the negative physical consequences and consequent treatment costs, and helps to slow down the aging process and is effective in improving the daily activities of the elderly. Manuscript Document
      • Open Access Article

        6 - The effect of 12 weeks aerobic training on TNF-α levels in the hippocampus and prefrontal cortex, and depression in rats with Alzheimer's disease
        Ehsan Mohammadikia Fereshteh Mohebbi Hossein Babaei
        Background: Exercise training plays an important role in combating Alzheimer's disease. Present study aimed to investigate the effect of 12 weeks aerobic training on the levels of tumor necrosis factor alpha (TNF-α) in the hippocampus and prefrontal cortex, and also dep Full Text
        Background: Exercise training plays an important role in combating Alzheimer's disease. Present study aimed to investigate the effect of 12 weeks aerobic training on the levels of tumor necrosis factor alpha (TNF-α) in the hippocampus and prefrontal cortex, and also depression in rats with Alzheimer's disease. Methods: The 40 Wistar rats were divided into four equal groups including saline (S), saline +training (ST), training +STZ (AT) and STZ (A). Alzheimer's was induced by injection of 3 mg/kg streptozotocin (STZ) into the ventricles of brain. The aerobic training program (each session lasted 30 minutes with 10-12 meters per minute speed) performed for 12 weeks and five sessions per week on a treadmill. The 48 hours after last training session, brain tissue (hippocampal and prefrontal cortex areas) was removed and TNF-α levels were measured by ELISA method. Data were evaluated using the statistical method of analysis of variance at a significant level (P <0.05). Result: TNF-α levels in the hippocampus were significantly higher in group A compared to S (p= 0.010), ST (p= 0.014) and AT (p= 0.041) groups. Moreover, no significant change was observed for TNF-α levels in prefrontal cortex in different groups (p= 0.276). In addition, a significant increase in inactivity duration (FST) was observed in group A compared to other groups (p <0.05) and also a significant decrease in sucrose preference (SPT) was observed in group A compared to other groups. (p<0.05). Conclusion: The present study findings indicated that, the positive effects of aerobic training in rats with Alzheimer's disease are exerted partly by modulating the levels of inflammatory factors such as TNF-α in the brain especially the hippocampus. Manuscript Document